相互作用
Dofetilide + Hydrochlorothiazide-irbesartan
重症度: 併用禁忌
Dofetilide and Hydrochlorothiazide-irbesartan: contraindicated interaction.
最終更新日
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概要
Hydrochlorothiazide can raise dofetilide levels and also causes hypokalemia and hypomagnesemia. Higher exposure and electrolyte disturbance increase the risk of QT prolongation and torsades de pointes.
この相互作用をわかりやすく説明すると
Dofetilide and Hydrochlorothiazide-irbesartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
なぜ起こるのか
Reduced renal tubular secretion of dofetilide plus thiazide-induced electrolyte depletion promotes QT prolongation.
対処法
Avoid the combination, as it is contraindicated in dofetilide labeling; choose a non-thiazide antihypertensive. Correct electrolytes and monitor ECG if dofetilide is used.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DofetilideとHydrochlorothiazide-irbesartanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydrochlorothiazide-irbesartanのその他の相互作用
Dofetilideのその他の相互作用
よくある質問
Can I take Dofetilide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as contraindicated. Dofetilide and Hydrochlorothiazide-irbesartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels and also causes hypokalemia and hypomagnesemia. Higher exposure and electrolyte disturbance increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Dofetilide and Hydrochlorothiazide-irbesartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as it is contraindicated in dofetilide labeling; choose a non-thiazide antihypertensive. Correct electrolytes and monitor ECG if dofetilide is used.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Hydrochlorothiazide-irbesartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
