Drug interactions
Dofetilide + Hydrochlorothiazide-irbesartan
Severity: Contraindicated
Dofetilide and Hydrochlorothiazide-irbesartan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise dofetilide levels and also causes hypokalemia and hypomagnesemia. Higher exposure and electrolyte disturbance increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Dofetilide and Hydrochlorothiazide-irbesartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Reduced renal tubular secretion of dofetilide plus thiazide-induced electrolyte depletion promotes QT prolongation.
What to do
Avoid the combination, as it is contraindicated in dofetilide labeling; choose a non-thiazide antihypertensive. Correct electrolytes and monitor ECG if dofetilide is used.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
- Benazepril + Hydrochlorothiazide-irbesartan Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as contraindicated. Dofetilide and Hydrochlorothiazide-irbesartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels and also causes hypokalemia and hypomagnesemia. Higher exposure and electrolyte disturbance increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Dofetilide and Hydrochlorothiazide-irbesartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as it is contraindicated in dofetilide labeling; choose a non-thiazide antihypertensive. Correct electrolytes and monitor ECG if dofetilide is used.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Hydrochlorothiazide-irbesartan page.
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