相互作用
Dolasetron + Thioridazine
重症度: 併用禁忌
Dolasetron and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.
この相互作用をわかりやすく説明すると
Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive potassium channel blockade producing marked QT prolongation.
対処法
Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DolasetronとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dolasetronのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Dolasetron with Thioridazine?
MediHelp rates the interaction as contraindicated. Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.
How serious is the interaction between Dolasetron and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
