相互作用
Dolasetron + Ziprasidone
重症度: 併用禁忌
Dolasetron and Ziprasidone: contraindicated interaction.
最終更新日
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概要
Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
この相互作用をわかりやすく説明すると
Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
なぜ起こるのか
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
対処法
Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DolasetronとZiprasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dolasetronのその他の相互作用
Ziprasidoneのその他の相互作用
よくある質問
Can I take Dolasetron with Ziprasidone?
MediHelp rates the interaction as contraindicated. Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
How serious is the interaction between Dolasetron and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
