相互作用
Doxycycline + Magnesium sulphate
重症度: 中等度
Doxycycline and Magnesium sulphate: moderate interaction.
最終更新日
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概要
Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
この相互作用をわかりやすく説明すると
Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
なぜ起こるのか
Chelation of doxycycline by divalent magnesium cations in the gastrointestinal tract, forming poorly absorbed complexes.
対処法
Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DoxycyclineとMagnesium sulphateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Magnesium sulphateのその他の相互作用
Doxycyclineのその他の相互作用
よくある質問
Can I take Doxycycline with Magnesium sulphate?
MediHelp rates the interaction as moderate. Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
How serious is the interaction between Doxycycline and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
