相互作用
Atracurium + Magnesium sulphate
重症度: 中等度
Atracurium and Magnesium sulphate: moderate interaction.
最終更新日
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概要
Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.
この相互作用をわかりやすく説明すると
Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Magnesium sulphate belongs to Cardiovascular.
なぜ起こるのか
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity at the neuromuscular junction, adding to competitive blockade.
対処法
Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、AtracuriumとMagnesium sulphateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Magnesium sulphateのその他の相互作用
Atracuriumのその他の相互作用
よくある質問
Can I take Atracurium with Magnesium sulphate?
MediHelp rates the interaction as moderate. Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.
How serious is the interaction between Atracurium and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
