相互作用
Elagolix + Ethinyl estradiol-drospirenone
重症度: 重大
Elagolix and Ethinyl estradiol-drospirenone: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Estrogen-containing contraceptives are expected to counteract elagolix's hypoestrogenic effect and reduce its efficacy. Elagolix may also lower hormonal contraceptive efficacy and is not itself a reliable contraceptive.
この相互作用をわかりやすく説明すると
Elagolix and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ethinyl estradiol-drospirenone belongs to Endocrine.
なぜ起こるのか
Pharmacodynamic antagonism: exogenous estrogen opposes elagolix's suppression of estrogen.
対処法
Use non-hormonal contraception during elagolix therapy and for one week after stopping. Avoid concurrent estrogen-containing contraceptives.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ElagolixとEthinyl estradiol-drospirenoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Ethinyl estradiol-drospirenoneのその他の相互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 併用禁忌
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 併用禁忌
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir 併用禁忌
- Ethinyl estradiol-drospirenone + Tranexamic acid 併用禁忌
- Aminocaproic acid + Ethinyl estradiol-drospirenone 重大
- Amobarbital + Ethinyl estradiol-drospirenone 重大
Elagolixのその他の相互作用
よくある質問
Can I take Elagolix with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as major. Elagolix and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogen-containing contraceptives are expected to counteract elagolix's hypoestrogenic effect and reduce its efficacy. Elagolix may also lower hormonal contraceptive efficacy and is not itself a reliable contraceptive.
How serious is the interaction between Elagolix and Ethinyl estradiol-drospirenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use non-hormonal contraception during elagolix therapy and for one week after stopping. Avoid concurrent estrogen-containing contraceptives.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
