相互作用
Desogestrel-ethinyl estradiol + Elagolix
重症度: 重大
Desogestrel-ethinyl estradiol and Elagolix: major interaction.
最終更新日
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概要
Elagolix lowers estrogen levels, while estrogen-containing contraceptives are expected to oppose this effect and reduce its efficacy. Elagolix is also not a reliable contraceptive and may reduce hormonal contraceptive exposure.
この相互作用をわかりやすく説明すると
Desogestrel-ethinyl estradiol and Elagolix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desogestrel-ethinyl estradiol belongs to Endocrine; Elagolix belongs to Musculoskeletal.
なぜ起こるのか
Pharmacodynamic antagonism between exogenous estrogen and elagolix-induced estrogen suppression.
対処法
Avoid estrogen-containing contraceptives and use non-hormonal contraception during elagolix therapy and for 1 week after stopping.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Desogestrel-ethinyl estradiolとElagolixの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desogestrel-ethinyl estradiolのその他の相互作用
Elagolixのその他の相互作用
よくある質問
Can I take Desogestrel-ethinyl estradiol with Elagolix?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Elagolix can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elagolix lowers estrogen levels, while estrogen-containing contraceptives are expected to oppose this effect and reduce its efficacy. Elagolix is also not a reliable contraceptive and may reduce hormonal contraceptive exposure.
How serious is the interaction between Desogestrel-ethinyl estradiol and Elagolix?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives and use non-hormonal contraception during elagolix therapy and for 1 week after stopping.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
