相互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mexiletine
重症度: 重大
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mexiletine: major interaction.
最終更新日
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概要
Cobicistat inhibits CYP2D6 and CYP3A4, which can raise mexiletine concentrations. Mexiletine has a narrow therapeutic index and elevated levels can cause neurotoxicity and arrhythmias.
この相互作用をわかりやすく説明すると
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cobicistat inhibits CYP2D6-mediated metabolism of mexiletine.
対処法
Avoid the combination where possible or reduce the mexiletine dose, with close clinical and ECG monitoring and mexiletine level checks if available.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Elvitegravir / cobicistat / emtricitabine / tenofovir dfとMexiletineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mexiletineのその他の相互作用
よくある質問
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Mexiletine?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits CYP2D6 and CYP3A4, which can raise mexiletine concentrations. Mexiletine has a narrow therapeutic index and elevated levels can cause neurotoxicity and arrhythmias.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or reduce the mexiletine dose, with close clinical and ECG monitoring and mexiletine level checks if available.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
