医薬品リファレンス
Mexiletine
Mexiletine is a medicine in the class cardiovascular. It is used for arrhythmias.
- 薬効分類: Cardiovascular
- 効能・効果: arrhythmias
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Cardiovascular
- ATCコード
- C01BB02
- 既知の相互作用
- 121 (併用禁忌: 2 · 重大: 16 · 中等度: 75 · 軽度: 28)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Class 1B antidysrhythmic; combines with fast Na channels & thereby inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity
成人の通常用量（添付文書の要約）
Ventricular Arrhythmias (Life-Threatening) Initial: 200 mg PO q8hr; may load with 400 mg followed by 200 mg PO q8hr if necessary for rapid control of ventricular arrhythmia
妊娠と授乳
- 妊娠
- Unknown No adequate human data. Animal studies showed no birth defects but more fetal loss (resorptions) at up to 4 times the human dose. Use only if the benefit outweighs the risk, for example for serious arrhythmias, with fetal monitoring.
- 授乳
- Safe Passes into milk at levels similar to the mother's blood. US label: consider another way of feeding the infant. LactMed: doses up to 600 mg daily give low milk levels that are not expected to harm the infant.
報告されている副作用
- Vomiting
- Nausea
- Dizziness
- Ataxia
- Heartburn
警告（枠囲み警告）
- National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction (MI) >6 days but <2 yr previously Average duration of treatment w/ encainide or flecainide in CAST was 10 months Applicability of CAST results to other populations (eg, patients without recent MI) is uncertain…
禁忌
- Hypersensitivity to mexiletine
- Cardiogenic shock, preexisting 2°/3° AV block without pacemaker
注意が必要な方
- Monitor and adjust dose to prevent QTc prolongation
- Use caution in CHF, hypotension, history of seizures
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (121)
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
- Dofetilide + Mexiletine Major
- Dronedarone + Mexiletine Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mexiletine Major
- Fluvoxamine + Mexiletine Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Mexiletineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Mexiletine used for?
Mexiletine is a medicine in the class cardiovascular. It is used for Arrhythmias.
What side effects have been reported with Mexiletine?
Vomiting, Nausea, Dizziness, Ataxia, Heartburn. Serious warning: National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with…
Can Mexiletine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Animal studies showed no birth defects but more fetal loss (resorptions) at up to 4 times the human dose. Use only if the benefit outweighs the risk, for example for serious arrhythmias, with fetal monitoring. Breastfeeding: Safe. Passes into milk at levels similar to the mother's blood. US label: consider another way of feeding the infant. LactMed: doses up to 600 mg daily give low milk levels that are not expected to harm the infant.
What does Mexiletine interact with?
MediHelp lists 121 known interactions for Mexiletine. Contraindicated: 2 · Major: 16 · Moderate: 75 · Minor: 28. The most serious include Fezolinetant, Pimozide, Alosetron.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
