相互作用
Amiodarone + Mexiletine
重症度: 重大
Amiodarone and Mexiletine: major interaction.
最終更新日
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概要
Amiodarone inhibits CYP2D6 and may raise mexiletine levels, and both drugs affect cardiac conduction. The combination can increase the risk of mexiletine toxicity, QT prolongation and proarrhythmia.
この相互作用をわかりやすく説明すると
Amiodarone and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Mexiletine belongs to Cardiovascular.
なぜ起こるのか
CYP2D6 inhibition by amiodarone plus additive electrophysiologic effects.
対処法
Monitor ECG including QTc and consider a lower mexiletine dose; watch for CNS and GI toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとMexiletineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mexiletineのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Mexiletine?
MediHelp rates the interaction as major. Amiodarone and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP2D6 and may raise mexiletine levels, and both drugs affect cardiac conduction. The combination can increase the risk of mexiletine toxicity, QT prolongation and proarrhythmia.
How serious is the interaction between Amiodarone and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG including QTc and consider a lower mexiletine dose; watch for CNS and GI toxicity.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
