相互作用
Fezolinetant + Mexiletine
重症度: 併用禁忌
Fezolinetant and Mexiletine: contraindicated interaction.
最終更新日
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概要
Fezolinetant is metabolized primarily by CYP1A2, and its exposure rises with CYP1A2 inhibitors. Mexiletine is a CYP1A2 inhibitor, so fezolinetant levels may increase, raising the risk of liver toxicity and other adverse effects. Labeling contraindicates use with CYP1A2 inhibitors.
この相互作用をわかりやすく説明すると
Fezolinetant and Mexiletine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fezolinetant belongs to Endocrine; Mexiletine belongs to Cardiovascular.
なぜ起こるのか
Mexiletine inhibits CYP1A2, reducing fezolinetant clearance.
対処法
Do not use together; choose another menopause vasomotor therapy. If mexiletine is required, stop fezolinetant.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FezolinetantとMexiletineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mexiletineのその他の相互作用
Fezolinetantのその他の相互作用
よくある質問
Can I take Fezolinetant with Mexiletine?
MediHelp rates the interaction as contraindicated. Fezolinetant and Mexiletine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized primarily by CYP1A2, and its exposure rises with CYP1A2 inhibitors. Mexiletine is a CYP1A2 inhibitor, so fezolinetant levels may increase, raising the risk of liver toxicity and other adverse effects. Labeling contraindicates use with CYP1A2 inhibitors.
How serious is the interaction between Fezolinetant and Mexiletine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose another menopause vasomotor therapy. If mexiletine is required, stop fezolinetant.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Pimozide, Alosetron, Amiodarone. The full list is on the Mexiletine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
