相互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine
重症度: 併用禁忌
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Stavudine: contraindicated interaction.
最終更新日
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概要
This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Adding stavudine duplicates the nucleoside backbone and increases risks of neuropathy, lipoatrophy and lactic acidosis without benefit.
この相互作用をわかりやすく説明すると
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Therapeutic duplication of nucleoside reverse transcriptase inhibitors, with additive mitochondrial toxicity.
対処法
Do not co-administer; stavudine should be stopped if the single-tablet regimen is used.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Elvitegravir / cobicistat / emtricitabine / tenofovir dfとStavudineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Stavudineのその他の相互作用
よくある質問
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Stavudine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Adding stavudine duplicates the nucleoside backbone and increases risks of neuropathy, lipoatrophy and lactic acidosis without benefit.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stavudine should be stopped if the single-tablet regimen is used.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Didanosine, Hydroxycarbamide, Zidovudine. The full list is on the Stavudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
