相互作用
Atidarsagene autotemcel + Stavudine
重症度: 重大
Atidarsagene autotemcel and Stavudine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Antiretrovirals can interfere with lentiviral transduction during manufacture of this gene therapy. Residual drug may reduce the efficacy of the product.
この相互作用をわかりやすく説明すると
Atidarsagene autotemcel and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Stavudine belongs to Anti Virals.
なぜ起こるのか
Stavudine inhibits reverse transcription, impairing lentiviral transduction.
対処法
Stop stavudine at least one month before mobilization and until apheresis is complete.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Atidarsagene autotemcelとStavudineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Stavudineのその他の相互作用
Atidarsagene autotemcelのその他の相互作用
よくある質問
Can I take Atidarsagene autotemcel with Stavudine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals can interfere with lentiviral transduction during manufacture of this gene therapy. Residual drug may reduce the efficacy of the product.
How serious is the interaction between Atidarsagene autotemcel and Stavudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop stavudine at least one month before mobilization and until apheresis is complete.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide. The full list is on the Stavudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
