相互作用
Enzalutamide + Lonafarnib
重症度: 併用禁忌
Enzalutamide and Lonafarnib: contraindicated interaction.
最終更新日
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概要
Lonafarnib is a sensitive CYP3A4 substrate, and enzalutamide's strong induction is expected to cut its exposure considerably. This could reduce efficacy, and labeling advises against strong or moderate inducers.
この相互作用をわかりやすく説明すると
Enzalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
なぜ起こるのか
CYP3A4 induction by enzalutamide increases lonafarnib metabolism.
対処法
Avoid the combination and seek an alternative antiandrogen. Monitor clinical response closely if it cannot be avoided.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EnzalutamideとLonafarnibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Enzalutamideのその他の相互作用
Lonafarnibのその他の相互作用
よくある質問
Can I take Enzalutamide with Lonafarnib?
MediHelp rates the interaction as contraindicated. Enzalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and enzalutamide's strong induction is expected to cut its exposure considerably. This could reduce efficacy, and labeling advises against strong or moderate inducers.
How serious is the interaction between Enzalutamide and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and seek an alternative antiandrogen. Monitor clinical response closely if it cannot be avoided.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
