相互作用
Enzalutamide + Isavuconazonium
重症度: 併用禁忌
Enzalutamide and Isavuconazonium: contraindicated interaction.
最終更新日
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概要
Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, and strong inducers markedly reduce its exposure. This can lead to antifungal failure in invasive infections, and labeling contraindicates strong inducers.
この相互作用をわかりやすく説明すると
Enzalutamide and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
なぜ起こるのか
Enzalutamide induces CYP3A4 and increases isavuconazole metabolism.
対処法
Do not coadminister; use an alternative antifungal such as liposomal amphotericin B or consider switching the antiandrogen. Monitor clinical response if the inducer was recently stopped.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、EnzalutamideとIsavuconazoniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Enzalutamideのその他の相互作用
Isavuconazoniumのその他の相互作用
よくある質問
Can I take Enzalutamide with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Enzalutamide and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate, and strong inducers markedly reduce its exposure. This can lead to antifungal failure in invasive infections, and labeling contraindicates strong inducers.
How serious is the interaction between Enzalutamide and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antifungal such as liposomal amphotericin B or consider switching the antiandrogen. Monitor clinical response if the inducer was recently stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
