相互作用
Enzalutamide + Mavacamten
重症度: 併用禁忌
Enzalutamide and Mavacamten: contraindicated interaction.
最終更新日
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概要
Mavacamten is cleared by CYP2C19 and CYP3A4, and enzalutamide induces both, lowering exposure and reducing therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.
この相互作用をわかりやすく説明すると
Enzalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Mavacamten belongs to Cardiovascular.
なぜ起こるのか
Induction of CYP2C19 and CYP3A4 by enzalutamide increases mavacamten clearance.
対処法
Avoid the combination; if enzalutamide is started or stopped in a mavacamten patient, check LVEF and gradient by echocardiography and adjust the dose.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、EnzalutamideとMavacamtenの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Enzalutamideのその他の相互作用
Mavacamtenのその他の相互作用
よくある質問
Can I take Enzalutamide with Mavacamten?
MediHelp rates the interaction as contraindicated. Enzalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared by CYP2C19 and CYP3A4, and enzalutamide induces both, lowering exposure and reducing therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.
How serious is the interaction between Enzalutamide and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if enzalutamide is started or stopped in a mavacamten patient, check LVEF and gradient by echocardiography and adjust the dose.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
