相互作用
Apalutamide + Mavacamten
重症度: 併用禁忌
Apalutamide and Mavacamten: contraindicated interaction.
最終更新日
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概要
Apalutamide can substantially reduce mavacamten exposure, which may result in loss of therapeutic effect on left ventricular outflow obstruction. Stopping the inducer later can also cause exposure to rise unexpectedly.
この相互作用をわかりやすく説明すると
Apalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Mavacamten belongs to Cardiovascular.
なぜ起こるのか
Apalutamide induces CYP2C19 and CYP3A4, the main enzymes that metabolize mavacamten.
対処法
Avoid the combination; use an alternative to apalutamide. Monitor echocardiographic response if the inducer is started or stopped.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、ApalutamideとMavacamtenの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apalutamideのその他の相互作用
Mavacamtenのその他の相互作用
よくある質問
Can I take Apalutamide with Mavacamten?
MediHelp rates the interaction as contraindicated. Apalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide can substantially reduce mavacamten exposure, which may result in loss of therapeutic effect on left ventricular outflow obstruction. Stopping the inducer later can also cause exposure to rise unexpectedly.
How serious is the interaction between Apalutamide and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative to apalutamide. Monitor echocardiographic response if the inducer is started or stopped.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
