相互作用
Enzalutamide + Nirmatrelvir
重症度: 併用禁忌
Enzalutamide and Nirmatrelvir: contraindicated interaction.
最終更新日
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概要
Strong CYP3A4 inducers markedly lower nirmatrelvir concentrations, risking loss of antiviral efficacy against SARS-CoV-2 and resistance. Labeling contraindicates the combination with inducers.
この相互作用をわかりやすく説明すると
Enzalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Nirmatrelvir belongs to Anti Virals.
なぜ起こるのか
Enzalutamide induces CYP3A4, accelerating nirmatrelvir clearance.
対処法
Do not use together; consider an alternative COVID-19 therapy such as remdesivir. Induction persists after stopping enzalutamide, so allow a washout before starting nirmatrelvir.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EnzalutamideとNirmatrelvirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Enzalutamideのその他の相互作用
Nirmatrelvirのその他の相互作用
よくある質問
Can I take Enzalutamide with Nirmatrelvir?
MediHelp rates the interaction as contraindicated. Enzalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A4 inducers markedly lower nirmatrelvir concentrations, risking loss of antiviral efficacy against SARS-CoV-2 and resistance. Labeling contraindicates the combination with inducers.
How serious is the interaction between Enzalutamide and Nirmatrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider an alternative COVID-19 therapy such as remdesivir. Induction persists after stopping enzalutamide, so allow a washout before starting nirmatrelvir.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
