相互作用
Apalutamide + Nirmatrelvir
重症度: 併用禁忌
Apalutamide and Nirmatrelvir: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Apalutamide markedly decreases nirmatrelvir concentrations, which may result in treatment failure for COVID-19 and potential resistance. The inducing effect persists after apalutamide is stopped.
この相互作用をわかりやすく説明すると
Apalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Nirmatrelvir belongs to Anti Virals.
なぜ起こるのか
Apalutamide induces CYP3A4, increasing the metabolism of nirmatrelvir.
対処法
Do not use together; consider another COVID-19 antiviral not affected by induction. Avoid starting nirmatrelvir soon after stopping apalutamide.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとNirmatrelvirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Apalutamideのその他の相互作用
Nirmatrelvirのその他の相互作用
よくある質問
Can I take Apalutamide with Nirmatrelvir?
MediHelp rates the interaction as contraindicated. Apalutamide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide markedly decreases nirmatrelvir concentrations, which may result in treatment failure for COVID-19 and potential resistance. The inducing effect persists after apalutamide is stopped.
How serious is the interaction between Apalutamide and Nirmatrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider another COVID-19 antiviral not affected by induction. Avoid starting nirmatrelvir soon after stopping apalutamide.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
