相互作用
Erythromycin + Revefenacin
重症度: 中等度
Erythromycin and Revefenacin: moderate interaction.
最終更新日
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概要
Erythromycin inhibits OATP1B1 and OATP1B3 transport, which may raise exposure to revefenacin's active metabolite. Increased systemic anticholinergic effects such as dry mouth, urinary retention and tachycardia may occur.
この相互作用をわかりやすく説明すると
Erythromycin and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Revefenacin belongs to Respiratory.
なぜ起こるのか
Inhibition of hepatic OATP1B1/1B3 uptake increases systemic exposure to revefenacin's active metabolite.
対処法
Prefer an alternative antibiotic when possible. If combined, monitor for systemic anticholinergic effects.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ErythromycinとRevefenacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Erythromycinのその他の相互作用
Revefenacinのその他の相互作用
よくある質問
Can I take Erythromycin with Revefenacin?
MediHelp rates the interaction as moderate. Erythromycin and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits OATP1B1 and OATP1B3 transport, which may raise exposure to revefenacin's active metabolite. Increased systemic anticholinergic effects such as dry mouth, urinary retention and tachycardia may occur.
How serious is the interaction between Erythromycin and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic when possible. If combined, monitor for systemic anticholinergic effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
