Drug interactions
Erythromycin + Revefenacin
Severity: Moderate
Erythromycin and Revefenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits OATP1B1 and OATP1B3 transport, which may raise exposure to revefenacin's active metabolite. Increased systemic anticholinergic effects such as dry mouth, urinary retention and tachycardia may occur.
What this interaction means in plain words
Erythromycin and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Revefenacin belongs to Respiratory.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake increases systemic exposure to revefenacin's active metabolite.
What to do
Prefer an alternative antibiotic when possible. If combined, monitor for systemic anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Erythromycin with Revefenacin?
MediHelp rates the interaction as moderate. Erythromycin and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits OATP1B1 and OATP1B3 transport, which may raise exposure to revefenacin's active metabolite. Increased systemic anticholinergic effects such as dry mouth, urinary retention and tachycardia may occur.
How serious is the interaction between Erythromycin and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic when possible. If combined, monitor for systemic anticholinergic effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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