相互作用
Dronedarone + Erythromycin
重症度: 併用禁忌
Dronedarone and Erythromycin: contraindicated interaction.
最終更新日
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概要
Erythromycin inhibits CYP3A4, raising dronedarone exposure, and itself prolongs the QTc interval. Dronedarone can in turn raise erythromycin levels, so torsades de pointes risk rises substantially.
この相互作用をわかりやすく説明すると
Dronedarone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Erythromycin belongs to Anti Bacterial.
なぜ起こるのか
CYP3A4 inhibition (raised dronedarone) plus additive QTc prolongation
対処法
Do not co-administer; use a non-macrolide antibiotic and monitor the ECG if exposure has occurred.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DronedaroneとErythromycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Erythromycinのその他の相互作用
Dronedaroneのその他の相互作用
よくある質問
Can I take Dronedarone with Erythromycin?
MediHelp rates the interaction as contraindicated. Dronedarone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin inhibits CYP3A4, raising dronedarone exposure, and itself prolongs the QTc interval. Dronedarone can in turn raise erythromycin levels, so torsades de pointes risk rises substantially.
How serious is the interaction between Dronedarone and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-macrolide antibiotic and monitor the ECG if exposure has occurred.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
