相互作用
Escitalopram + Procarbazine
重症度: 併用禁忌
Escitalopram and Procarbazine: contraindicated interaction.
最終更新日
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概要
Procarbazine has weak monoamine oxidase-inhibiting properties, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
この相互作用をわかりやすく説明すると
Escitalopram and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Escitalopram belongs to Central Nervous System; Procarbazine belongs to Oncology.
なぜ起こるのか
Inhibition of monoamine oxidase combined with an SSRI activity leading to excess serotonergic stimulation
対処法
Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EscitalopramとProcarbazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Escitalopramのその他の相互作用
Procarbazineのその他の相互作用
よくある質問
Can I take Escitalopram with Procarbazine?
MediHelp rates the interaction as contraindicated. Escitalopram and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has weak monoamine oxidase-inhibiting properties, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
How serious is the interaction between Escitalopram and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
