相互作用
Ethanol + Tinidazole
重症度: 重大
Ethanol and Tinidazole: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Drinking alcohol during tinidazole therapy can cause a disulfiram-like reaction with flushing, nausea, vomiting, abdominal cramps, headache and palpitations. This effect can persist after the last tinidazole dose.
この相互作用をわかりやすく説明すると
Ethanol and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Proposed inhibition of aldehyde dehydrogenase, causing acetaldehyde accumulation, though the mechanism is debated.
対処法
Advise patients to avoid alcohol and ethanol-containing products during treatment and for 3 days after the last dose. Counsel on hidden sources such as some liquid medicines.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EthanolとTinidazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tinidazoleのその他の相互作用
よくある質問
Can I take Ethanol with Tinidazole?
MediHelp rates the interaction as major. Ethanol and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Drinking alcohol during tinidazole therapy can cause a disulfiram-like reaction with flushing, nausea, vomiting, abdominal cramps, headache and palpitations. This effect can persist after the last tinidazole dose.
How serious is the interaction between Ethanol and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol and ethanol-containing products during treatment and for 3 days after the last dose. Counsel on hidden sources such as some liquid medicines.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Fexinidazole, Lopinavir. The full list is on the Tinidazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
