相互作用
Lopinavir + Tinidazole
重症度: 重大
Lopinavir and Tinidazole: major interaction.
最終更新日
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概要
Lopinavir/ritonavir oral solution contains a large amount of ethanol, and tinidazole can cause a disulfiram-like reaction with alcohol, producing flushing, nausea, vomiting and palpitations. Lopinavir may also raise tinidazole exposure through CYP3A4 inhibition, although the alcohol content is the main concern.
この相互作用をわかりやすく説明すると
Lopinavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
なぜ起こるのか
Ethanol in the oral solution combined with tinidazole's disulfiram-like effect, plus possible CYP3A4 inhibition by the ritonavir component of the co-formulation.
対処法
Avoid the lopinavir/ritonavir oral solution during tinidazole therapy and for 3 days after the last dose; use the tablet formulation if the combination is necessary.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LopinavirとTinidazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tinidazoleのその他の相互作用
Lopinavirのその他の相互作用
よくある質問
Can I take Lopinavir with Tinidazole?
MediHelp rates the interaction as major. Lopinavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir/ritonavir oral solution contains a large amount of ethanol, and tinidazole can cause a disulfiram-like reaction with alcohol, producing flushing, nausea, vomiting and palpitations. Lopinavir may also raise tinidazole exposure through CYP3A4 inhibition, although the alcohol content is the main concern.
How serious is the interaction between Lopinavir and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the lopinavir/ritonavir oral solution during tinidazole therapy and for 3 days after the last dose; use the tablet formulation if the combination is necessary.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
