相互作用
Amiodarone + Tinidazole
重症度: 中等度
Amiodarone and Tinidazole: moderate interaction.
最終更新日
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概要
Tinidazole is partly metabolized by CYP3A4, and amiodarone is only a weak to moderate CYP3A4 inhibitor, so a significant rise in tinidazole is unlikely. The more relevant concern is that both drugs may prolong the QT interval, with a risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Amiodarone and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tinidazole belongs to Anti Parasitic.
なぜ起こるのか
Additive QT prolongation, with a minor possible pharmacokinetic effect through CYP3A4 inhibition by amiodarone.
対処法
Obtain a baseline ECG, keep potassium and magnesium normal, and monitor QTc during co-administration. Consider an alternative antimicrobial if the QTc becomes prolonged.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとTinidazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tinidazoleのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Tinidazole?
MediHelp rates the interaction as moderate. Amiodarone and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tinidazole is partly metabolized by CYP3A4, and amiodarone is only a weak to moderate CYP3A4 inhibitor, so a significant rise in tinidazole is unlikely. The more relevant concern is that both drugs may prolong the QT interval, with a risk of torsades de pointes.
How serious is the interaction between Amiodarone and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, keep potassium and magnesium normal, and monitor QTc during co-administration. Consider an alternative antimicrobial if the QTc becomes prolonged.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
