相互作用
Ritonavir + Tinidazole
重症度: 重大
Ritonavir and Tinidazole: major interaction.
最終更新日
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概要
Ritonavir oral solution contains ethanol, and tinidazole can provoke a disulfiram-like reaction with alcohol, causing flushing, vomiting, tachycardia and headache. The risk is tied to the alcohol-containing liquid formulation rather than ritonavir itself.
この相互作用をわかりやすく説明すると
Ritonavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ritonavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
なぜ起こるのか
Ethanol in the ritonavir oral solution combined with tinidazole's disulfiram-like inhibition of alcohol metabolism.
対処法
Avoid ritonavir oral solution during tinidazole treatment and for 3 days after; use ritonavir tablets or another formulation if coadministration is needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RitonavirとTinidazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tinidazoleのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Ritonavir with Tinidazole?
MediHelp rates the interaction as major. Ritonavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir oral solution contains ethanol, and tinidazole can provoke a disulfiram-like reaction with alcohol, causing flushing, vomiting, tachycardia and headache. The risk is tied to the alcohol-containing liquid formulation rather than ritonavir itself.
How serious is the interaction between Ritonavir and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ritonavir oral solution during tinidazole treatment and for 3 days after; use ritonavir tablets or another formulation if coadministration is needed.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
