相互作用
Etonogestrel + Lesinurad
重症度: 中等度
Etonogestrel and Lesinurad: moderate interaction.
最終更新日
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概要
Lesinurad is a weak CYP3A inducer and may lower exposure to hormonal contraceptives metabolized by CYP3A4. This could reduce contraceptive efficacy and risk unintended pregnancy.
この相互作用をわかりやすく説明すると
Etonogestrel and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etonogestrel belongs to Endocrine; Lesinurad belongs to Genitourinary.
なぜ起こるのか
Weak induction of CYP3A4 by lesinurad increases metabolism of the progestin.
対処法
Advise an additional nonhormonal contraceptive method while lesinurad is used. Note that lesinurad has been discontinued in many markets.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EtonogestrelとLesinuradの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lesinuradのその他の相互作用
Etonogestrelのその他の相互作用
よくある質問
Can I take Etonogestrel with Lesinurad?
MediHelp rates the interaction as moderate. Etonogestrel and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad is a weak CYP3A inducer and may lower exposure to hormonal contraceptives metabolized by CYP3A4. This could reduce contraceptive efficacy and risk unintended pregnancy.
How serious is the interaction between Etonogestrel and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional nonhormonal contraceptive method while lesinurad is used. Note that lesinurad has been discontinued in many markets.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
