相互作用
Everolimus + Ritonavir
重症度: 併用禁忌
Everolimus and Ritonavir: contraindicated interaction.
最終更新日
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概要
Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can markedly raise everolimus exposure. This increases the risk of mTOR inhibitor toxicity such as infections, myelosuppression, hyperglycemia, hyperlipidemia, stomatitis and pneumonitis.
この相互作用をわかりやすく説明すると
Everolimus and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Everolimus belongs to Oncology; Ritonavir belongs to Anti Virals.
なぜ起こるのか
Ritonavir inhibits intestinal and hepatic CYP3A4 and P-glycoprotein, reducing everolimus clearance and increasing absorption.
対処法
Avoid concomitant use and select an antiretroviral regimen without strong CYP3A4 inhibition. If unavoidable, use only with specialist oversight, major everolimus dose reduction and therapeutic drug monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EverolimusとRitonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Everolimusのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Everolimus with Ritonavir?
MediHelp rates the interaction as contraindicated. Everolimus and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can markedly raise everolimus exposure. This increases the risk of mTOR inhibitor toxicity such as infections, myelosuppression, hyperglycemia, hyperlipidemia, stomatitis and pneumonitis.
How serious is the interaction between Everolimus and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an antiretroviral regimen without strong CYP3A4 inhibition. If unavoidable, use only with specialist oversight, major everolimus dose reduction and therapeutic drug monitoring.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
