相互作用
Finerenone + Ritonavir
重症度: 併用禁忌
Finerenone and Ritonavir: contraindicated interaction.
最終更新日
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概要
Ritonavir strongly inhibits CYP3A4 and markedly raises finerenone exposure. This increases the risk of hyperkalemia, hypotension and renal function decline.
この相互作用をわかりやすく説明すると
Finerenone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Finerenone belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
なぜ起こるのか
Strong CYP3A4 inhibition by ritonavir reduces the oxidative metabolism of finerenone.
対処法
Do not use finerenone with ritonavir or other strong CYP3A4 inhibitors. Choose an alternative antiretroviral or withhold finerenone while the inhibitor is needed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FinerenoneとRitonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Finerenoneのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Finerenone with Ritonavir?
MediHelp rates the interaction as contraindicated. Finerenone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and markedly raises finerenone exposure. This increases the risk of hyperkalemia, hypotension and renal function decline.
How serious is the interaction between Finerenone and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use finerenone with ritonavir or other strong CYP3A4 inhibitors. Choose an alternative antiretroviral or withhold finerenone while the inhibitor is needed.
What other medicines interact with Finerenone?
MediHelp also lists interactions of Finerenone with, for example, Carbamazepine, Clarithromycin, Ensitrelvir. The full list is on the Finerenone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
