Drug interactions
Finerenone + Ritonavir
Severity: Contraindicated
Finerenone and Ritonavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and markedly raises finerenone exposure. This increases the risk of hyperkalemia, hypotension and renal function decline.
What this interaction means in plain words
Finerenone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Finerenone belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Strong CYP3A4 inhibition by ritonavir reduces the oxidative metabolism of finerenone.
What to do
Do not use finerenone with ritonavir or other strong CYP3A4 inhibitors. Choose an alternative antiretroviral or withhold finerenone while the inhibitor is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Finerenone with Ritonavir?
MediHelp rates the interaction as contraindicated. Finerenone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and markedly raises finerenone exposure. This increases the risk of hyperkalemia, hypotension and renal function decline.
How serious is the interaction between Finerenone and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use finerenone with ritonavir or other strong CYP3A4 inhibitors. Choose an alternative antiretroviral or withhold finerenone while the inhibitor is needed.
What other medicines interact with Finerenone?
MediHelp also lists interactions of Finerenone with, for example, Carbamazepine, Clarithromycin, Ensitrelvir. The full list is on the Finerenone page.
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