相互作用
Fingolimod + Ponesimod
重症度: 併用禁忌
Fingolimod and Ponesimod: contraindicated interaction.
最終更新日
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概要
Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.
この相互作用をわかりやすく説明すると
Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fingolimod belongs to Central Nervous System; Ponesimod belongs to Central Nervous System.
なぜ起こるのか
Duplicate S1P receptor modulation producing additive negative chronotropic and immunosuppressive effects.
対処法
Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FingolimodとPonesimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fingolimodのその他の相互作用
Ponesimodのその他の相互作用
よくある質問
Can I take Fingolimod with Ponesimod?
MediHelp rates the interaction as contraindicated. Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.
How serious is the interaction between Fingolimod and Ponesimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
