相互作用
Fingolimod + Siponimod
重症度: 併用禁忌
Fingolimod and Siponimod: contraindicated interaction.
最終更新日
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概要
Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.
この相互作用をわかりやすく説明すると
Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fingolimod belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
なぜ起こるのか
Duplicate S1P receptor modulation with additive negative chronotropic and immunosuppressive effects.
対処法
Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FingolimodとSiponimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fingolimodのその他の相互作用
Siponimodのその他の相互作用
よくある質問
Can I take Fingolimod with Siponimod?
MediHelp rates the interaction as contraindicated. Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.
How serious is the interaction between Fingolimod and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
