相互作用
Fluvoxamine + Mavacamten
重症度: 併用禁忌
Fluvoxamine and Mavacamten: contraindicated interaction.
最終更新日
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概要
Mavacamten is metabolised largely by CYP2C19, which fluvoxamine strongly inhibits. Higher exposure can reduce ejection fraction and cause heart failure due to systolic dysfunction.
この相互作用をわかりやすく説明すると
Fluvoxamine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
なぜ起こるのか
Fluvoxamine inhibits CYP2C19 (and CYP3A4) and reduces mavacamten clearance.
対処法
Avoid the combination and select another antidepressant. If fluvoxamine is started or stopped in a patient on mavacamten, monitor LVEF and adjust the dose per labeling.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FluvoxamineとMavacamtenの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluvoxamineのその他の相互作用
Mavacamtenのその他の相互作用
よくある質問
Can I take Fluvoxamine with Mavacamten?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is metabolised largely by CYP2C19, which fluvoxamine strongly inhibits. Higher exposure can reduce ejection fraction and cause heart failure due to systolic dysfunction.
How serious is the interaction between Fluvoxamine and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select another antidepressant. If fluvoxamine is started or stopped in a patient on mavacamten, monitor LVEF and adjust the dose per labeling.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
