相互作用
Glycopyrrolate inhaled + Tiotropium
重症度: 重大
Glycopyrrolate inhaled and Tiotropium: major interaction.
最終更新日 出典: US FDA label
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概要
Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy without added benefit. This increases the risk of anticholinergic adverse effects such as dry mouth, urinary retention and glaucoma worsening.
この相互作用をわかりやすく説明すると
Glycopyrrolate inhaled and Tiotropium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Duplicate muscarinic receptor antagonism.
対処法
Do not use two long-acting muscarinic antagonists together; choose one agent.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Glycopyrrolate inhaledとTiotropiumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Tiotropiumのその他の相互作用
よくある質問
Can I take Glycopyrrolate inhaled with Tiotropium?
MediHelp rates the interaction as major. Glycopyrrolate inhaled and Tiotropium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy without added benefit. This increases the risk of anticholinergic adverse effects such as dry mouth, urinary retention and glaucoma worsening.
How serious is the interaction between Glycopyrrolate inhaled and Tiotropium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two long-acting muscarinic antagonists together; choose one agent.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Indacaterol-glycopyrronium, Revefenacin, Umeclidinium. The full list is on the Tiotropium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
