相互作用
Indacaterol-glycopyrronium + Tiotropium
重症度: 重大
Indacaterol-glycopyrronium and Tiotropium: major interaction.
最終更新日 出典: US FDA label
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概要
Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy and increases anticholinergic effects such as dry mouth, urinary retention and glaucoma risk without proven added benefit.
この相互作用をわかりやすく説明すると
Indacaterol-glycopyrronium and Tiotropium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Tiotropium belongs to Respiratory.
なぜ起こるのか
Duplicate muscarinic receptor antagonism leading to additive anticholinergic exposure.
対処法
Avoid concurrent use and keep only one long-acting muscarinic antagonist. If a switch is made, stop the previous agent.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、Indacaterol-glycopyrroniumとTiotropiumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Indacaterol-glycopyrroniumのその他の相互作用
Tiotropiumのその他の相互作用
よくある質問
Can I take Indacaterol-glycopyrronium with Tiotropium?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Tiotropium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy and increases anticholinergic effects such as dry mouth, urinary retention and glaucoma risk without proven added benefit.
How serious is the interaction between Indacaterol-glycopyrronium and Tiotropium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep only one long-acting muscarinic antagonist. If a switch is made, stop the previous agent.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
