相互作用
Tiotropium + Umeclidinium bromide
重症度: 重大
Tiotropium and Umeclidinium bromide: major interaction.
最終更新日 出典: US FDA label
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概要
Both are long-acting inhaled muscarinic antagonists, so using them together duplicates therapy without clear added benefit and increases anticholinergic adverse effects. These include dry mouth, urinary retention, glaucoma worsening and tachycardia.
この相互作用をわかりやすく説明すると
Tiotropium and Umeclidinium bromide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Duplicate muscarinic receptor antagonism with additive systemic anticholinergic exposure.
対処法
Avoid concurrent use and choose a single long-acting antimuscarinic. If one is replaced, stop the first before starting the second.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、TiotropiumとUmeclidinium bromideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Tiotropiumのその他の相互作用
よくある質問
Can I take Tiotropium with Umeclidinium bromide?
MediHelp rates the interaction as major. Tiotropium and Umeclidinium bromide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are long-acting inhaled muscarinic antagonists, so using them together duplicates therapy without clear added benefit and increases anticholinergic adverse effects. These include dry mouth, urinary retention, glaucoma worsening and tachycardia.
How serious is the interaction between Tiotropium and Umeclidinium bromide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single long-acting antimuscarinic. If one is replaced, stop the first before starting the second.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
