相互作用
Tiotropium + Umeclidinium bromide / vilanterol inhaled
重症度: 重大
Tiotropium and Umeclidinium bromide / vilanterol inhaled: major interaction.
最終更新日
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概要
Both tiotropium and umeclidinium are long-acting inhaled antimuscarinics, so combining them duplicates therapy. This increases anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and worsening narrow-angle glaucoma without added benefit.
この相互作用をわかりやすく説明すると
Tiotropium and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Duplicate long-acting muscarinic antagonism producing additive anticholinergic effects.
対処法
Avoid concurrent use and keep only one long-acting antimuscarinic. Stop one product and monitor for anticholinergic effects if the combination was used.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、TiotropiumとUmeclidinium bromide / vilanterol inhaledの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tiotropiumのその他の相互作用
よくある質問
Can I take Tiotropium with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Tiotropium and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both tiotropium and umeclidinium are long-acting inhaled antimuscarinics, so combining them duplicates therapy. This increases anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and worsening narrow-angle glaucoma without added benefit.
How serious is the interaction between Tiotropium and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep only one long-acting antimuscarinic. Stop one product and monitor for anticholinergic effects if the combination was used.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
