相互作用
Haloperidol + Levoketoconazole
重症度: 併用禁忌
Haloperidol and Levoketoconazole: contraindicated interaction.
最終更新日
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概要
Levoketoconazole prolongs the QT interval and strongly inhibits CYP3A4, which can raise haloperidol levels. The combination markedly increases the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Haloperidol and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
なぜ起こるのか
Additive QT prolongation with strong CYP3A4 inhibition increasing haloperidol exposure.
対処法
Avoid the combination and select a non-QT-prolonging antipsychotic. If unavoidable, monitor the ECG and electrolytes closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、HaloperidolとLevoketoconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Haloperidolのその他の相互作用
Levoketoconazoleのその他の相互作用
よくある質問
Can I take Haloperidol with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Haloperidol and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole prolongs the QT interval and strongly inhibits CYP3A4, which can raise haloperidol levels. The combination markedly increases the risk of torsades de pointes.
How serious is the interaction between Haloperidol and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-QT-prolonging antipsychotic. If unavoidable, monitor the ECG and electrolytes closely.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
