相互作用
Haloperidol + Ziprasidone
重症度: 併用禁忌
Haloperidol and Ziprasidone: contraindicated interaction.
最終更新日
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概要
Both antipsychotics prolong the QT interval, and ziprasidone is among the more QT-active agents. Combining them increases the risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Haloperidol and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
なぜ起こるのか
Additive pharmacodynamic QT prolongation through hERG potassium channel blockade.
対処法
Do not combine; use a single antipsychotic. If switching, allow appropriate washout and check ECG and electrolytes.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、HaloperidolとZiprasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Haloperidolのその他の相互作用
Ziprasidoneのその他の相互作用
よくある質問
Can I take Haloperidol with Ziprasidone?
MediHelp rates the interaction as contraindicated. Haloperidol and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both antipsychotics prolong the QT interval, and ziprasidone is among the more QT-active agents. Combining them increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Haloperidol and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single antipsychotic. If switching, allow appropriate washout and check ECG and electrolytes.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
