相互作用
Imatinib + Ponatinib
重症度: 重大
Imatinib and Ponatinib: major interaction.
最終更新日
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概要
Imatinib may increase ponatinib exposure, which carries risks of arterial occlusion, heart failure, hepatotoxicity and pancreatitis. Both are BCR-ABL inhibitors, so the combination is rarely rational.
この相互作用をわかりやすく説明すると
Imatinib and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Ponatinib belongs to Oncology.
なぜ起こるのか
Imatinib inhibits CYP3A4, a main route of ponatinib metabolism, and both drugs have overlapping toxicities.
対処法
Avoid combining the two. If coadministration is unavoidable, monitor for vascular events, liver function and pancreatitis and consider a reduced ponatinib dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ImatinibとPonatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Imatinibのその他の相互作用
Ponatinibのその他の相互作用
よくある質問
Can I take Imatinib with Ponatinib?
MediHelp rates the interaction as major. Imatinib and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib may increase ponatinib exposure, which carries risks of arterial occlusion, heart failure, hepatotoxicity and pancreatitis. Both are BCR-ABL inhibitors, so the combination is rarely rational.
How serious is the interaction between Imatinib and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two. If coadministration is unavoidable, monitor for vascular events, liver function and pancreatitis and consider a reduced ponatinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
