相互作用
Influenza virus vaccine quadrivalent intranasal + Siponimod
重症度: 併用禁忌
Influenza virus vaccine quadrivalent intranasal and Siponimod: contraindicated interaction.
最終更新日
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概要
The intranasal influenza vaccine contains live attenuated virus, which could cause vaccine-strain infection in a patient with siponimod-induced lymphopenia. Immune suppression also makes the vaccine response unreliable. Live vaccines should not be given during siponimod therapy.
この相互作用をわかりやすく説明すると
Influenza virus vaccine quadrivalent intranasal and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Lymphocyte sequestration by S1P receptor modulation impairs control of live attenuated virus replication.
対処法
Avoid live attenuated vaccines during siponimod and for about 4 weeks after discontinuation; use an inactivated influenza vaccine instead. If a live vaccine is needed, give it at least 4 weeks before starting siponimod.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Influenza virus vaccine quadrivalent intranasalとSiponimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Siponimodのその他の相互作用
よくある質問
Can I take Influenza virus vaccine quadrivalent intranasal with Siponimod?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which could cause vaccine-strain infection in a patient with siponimod-induced lymphopenia. Immune suppression also makes the vaccine response unreliable. Live vaccines should not be given during siponimod therapy.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live attenuated vaccines during siponimod and for about 4 weeks after discontinuation; use an inactivated influenza vaccine instead. If a live vaccine is needed, give it at least 4 weeks before starting siponimod.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
