相互作用
Fluconazole + Siponimod
重症度: 併用禁忌
Fluconazole and Siponimod: contraindicated interaction.
最終更新日
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概要
Fluconazole inhibits both CYP2C9 and CYP3A4, the main pathways clearing siponimod, and can substantially raise siponimod exposure. This increases the risk of bradyarrhythmia, infections, liver injury and other dose-related effects.
この相互作用をわかりやすく説明すると
Fluconazole and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Siponimod belongs to Central Nervous System.
なぜ起こるのか
Combined moderate inhibition of CYP2C9 and CYP3A4 by fluconazole reduces siponimod clearance.
対処法
Do not coadminister; siponimod labeling advises against use with drugs that moderately inhibit both CYP2C9 and CYP3A4. Choose a different antifungal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FluconazoleとSiponimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluconazoleのその他の相互作用
Siponimodのその他の相互作用
よくある質問
Can I take Fluconazole with Siponimod?
MediHelp rates the interaction as contraindicated. Fluconazole and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole inhibits both CYP2C9 and CYP3A4, the main pathways clearing siponimod, and can substantially raise siponimod exposure. This increases the risk of bradyarrhythmia, infections, liver injury and other dose-related effects.
How serious is the interaction between Fluconazole and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; siponimod labeling advises against use with drugs that moderately inhibit both CYP2C9 and CYP3A4. Choose a different antifungal.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
