相互作用
Insulin degludec + Pasireotide
重症度: 重大
Insulin degludec and Pasireotide: major interaction.
最終更新日
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概要
Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
この相互作用をわかりやすく説明すると
Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Pasireotide belongs to Endocrine.
なぜ起こるのか
Pasireotide suppresses insulin and incretin secretion (GLP-1 and GIP), producing hyperglycemia.
対処法
Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Insulin degludecとPasireotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Insulin degludecのその他の相互作用
Pasireotideのその他の相互作用
よくある質問
Can I take Insulin degludec with Pasireotide?
MediHelp rates the interaction as major. Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
How serious is the interaction between Insulin degludec and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
