相互作用
Isavuconazonium + Pimozide
重症度: 併用禁忌
Isavuconazonium and Pimozide: contraindicated interaction.
最終更新日
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概要
Isavuconazole is a moderate CYP3A4 inhibitor, and pimozide is a CYP3A4 substrate with a narrow margin of safety. Higher pimozide levels can cause serious QT prolongation and ventricular arrhythmias, and other azoles are contraindicated with pimozide.
この相互作用をわかりやすく説明すると
Isavuconazonium and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Pimozide belongs to Central Nervous System.
なぜ起こるのか
CYP3A4 inhibition by isavuconazole raises pimozide concentrations, adding to its QT liability.
対処法
Avoid concomitant use and choose a different antifungal or antipsychotic. If unavoidable, close ECG monitoring is required.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、IsavuconazoniumとPimozideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pimozideのその他の相互作用
Isavuconazoniumのその他の相互作用
よくある質問
Can I take Isavuconazonium with Pimozide?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isavuconazole is a moderate CYP3A4 inhibitor, and pimozide is a CYP3A4 substrate with a narrow margin of safety. Higher pimozide levels can cause serious QT prolongation and ventricular arrhythmias, and other azoles are contraindicated with pimozide.
How serious is the interaction between Isavuconazonium and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a different antifungal or antipsychotic. If unavoidable, close ECG monitoring is required.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
