相互作用
Carbamazepine + Isavuconazonium
重症度: 併用禁忌
Carbamazepine and Isavuconazonium: contraindicated interaction.
最終更新日
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概要
Carbamazepine induces CYP3A4 and greatly reduces isavuconazole exposure, risking treatment failure of serious fungal infection. Labeling contraindicates strong CYP3A4 inducers.
この相互作用をわかりやすく説明すると
Carbamazepine and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
なぜ起こるのか
Carbamazepine induces CYP3A4, increasing isavuconazole clearance.
対処法
Do not coadminister; use a non-inducing anticonvulsant or an alternative antifungal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、CarbamazepineとIsavuconazoniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbamazepineのその他の相互作用
Isavuconazoniumのその他の相互作用
よくある質問
Can I take Carbamazepine with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Carbamazepine and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine induces CYP3A4 and greatly reduces isavuconazole exposure, risking treatment failure of serious fungal infection. Labeling contraindicates strong CYP3A4 inducers.
How serious is the interaction between Carbamazepine and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-inducing anticonvulsant or an alternative antifungal.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
