相互作用
Ketoconazole + Rifaximin
重症度: 中等度
Ketoconazole and Rifaximin: moderate interaction.
最終更新日
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概要
Ketoconazole inhibits P-glycoprotein and may increase absorbed rifaximin. Because baseline systemic exposure is very low, the impact is usually small but could matter in severe hepatic dysfunction.
この相互作用をわかりやすく説明すると
Ketoconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Rifaximin belongs to Anti Bacterial.
なぜ起こるのか
P-glycoprotein inhibition by ketoconazole decreases rifaximin efflux.
対処法
Monitor for rifaximin adverse effects and avoid dose escalation, particularly in hepatic impairment.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、KetoconazoleとRifaximinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Rifaximinのその他の相互作用
Ketoconazoleのその他の相互作用
よくある質問
Can I take Ketoconazole with Rifaximin?
MediHelp rates the interaction as moderate. Ketoconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole inhibits P-glycoprotein and may increase absorbed rifaximin. Because baseline systemic exposure is very low, the impact is usually small but could matter in severe hepatic dysfunction.
How serious is the interaction between Ketoconazole and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects and avoid dose escalation, particularly in hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
