相互作用
Lamivudine + Sorbitol
重症度: 中等度
Lamivudine and Sorbitol: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Sorbitol-containing liquid medicines taken with lamivudine oral solution lower lamivudine exposure in a dose-related way. Reduced exposure may lead to inadequate viral suppression and resistance, especially in children.
この相互作用をわかりやすく説明すると
Lamivudine and Sorbitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamivudine belongs to Anti Virals; Sorbitol belongs to Gastrointestinal Tract.
なぜ起こるのか
Sorbitol appears to reduce lamivudine absorption, possibly through osmotic effects on the gut; the mechanism is not fully established.
対処法
Avoid regular co-administration of sorbitol-containing solutions with lamivudine where possible. If unavoidable, monitor viral load closely or use lamivudine tablets or a sorbitol-free formulation.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LamivudineとSorbitolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Lamivudineのその他の相互作用
Sorbitolのその他の相互作用
よくある質問
Can I take Lamivudine with Sorbitol?
MediHelp rates the interaction as moderate. Lamivudine and Sorbitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorbitol-containing liquid medicines taken with lamivudine oral solution lower lamivudine exposure in a dose-related way. Reduced exposure may lead to inadequate viral suppression and resistance, especially in children.
How serious is the interaction between Lamivudine and Sorbitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular co-administration of sorbitol-containing solutions with lamivudine where possible. If unavoidable, monitor viral load closely or use lamivudine tablets or a sorbitol-free formulation.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
