相互作用
Levoketoconazole + Ribociclib
重症度: 併用禁忌
Levoketoconazole and Ribociclib: contraindicated interaction.
最終更新日
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概要
Levoketoconazole is a strong CYP3A4 inhibitor that increases ribociclib exposure, and both drugs prolong the QT interval. Ribociclib may also modestly raise levoketoconazole levels, so arrhythmia risk is substantially increased.
この相互作用をわかりやすく説明すると
Levoketoconazole and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Ribociclib belongs to Oncology.
なぜ起こるのか
CYP3A4 inhibition raising ribociclib exposure combined with additive QTc prolongation.
対処法
Avoid the combination, and consider alternative therapy for either drug. If a strong inhibitor is unavoidable, reduce ribociclib to 400 mg daily with close ECG and electrolyte monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、LevoketoconazoleとRibociclibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ribociclibのその他の相互作用
Levoketoconazoleのその他の相互作用
よくある質問
Can I take Levoketoconazole with Ribociclib?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor that increases ribociclib exposure, and both drugs prolong the QT interval. Ribociclib may also modestly raise levoketoconazole levels, so arrhythmia risk is substantially increased.
How serious is the interaction between Levoketoconazole and Ribociclib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and consider alternative therapy for either drug. If a strong inhibitor is unavoidable, reduce ribociclib to 400 mg daily with close ECG and electrolyte monitoring.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
